There are multiple types of tests available for individuals suspected of having COVID-19, each looking for different targets and using different technologies to detect SARS-CoV-2. The range of options can make understanding how tests compare confusing. In fact, a recent online survey found only 30% of people in the US know the difference between two of the most widely used tests: PCR and antigen [1]. Here are some of the key differences, and perhaps surprising similarities, between these two commonly used test options...