New Study Just Completed SaltStable LS Advanced™ Proven to Deliver 8 Drugs Simultaneously*! SaltStable LS Advanced™ Transdermal Study Transdermal Study Contact Us for Details STUDY Evaluation of the Percutaneous Absorption of Ketamine HCl + Gabapentin + Clonidine HCl + Baclofen, In SaltStable LS Advanced™, Into Human Skin, In Vitro, Using the Franz Skin Finite Dose Model Using Humco’s SaltStable LS Advanced™ the study was designed to evaluate the percutaneous absorption pharmacokinetics of ketamine HCl, gabapentin, clonidine HCl and baclofen. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. The four drugs were selected TESTED FORMULA due to their frequent use in compounding topical pain formulations along with compounding multiple actives in one formulation. The formula was tested on standardized sections with Salt Stable LS, transdermal compounding base, for the percutaneous absorption of ketamine HCl, gabapentin, clonidine HCl and baclofen over a 48-hour dose period. At pre-selected times after dose application, the dermal receptor solution was removed in its entirety, replaced with fresh receptor solution, and an aliquot saved for subsequent analysis. High Performance Liquid Chromatography (HPLC) analyzed the samples. RESULTS Humco’s SaltStable LS Advanced™ is proven to deliver multiple drugs beyond the stratum corneum, simultaneously into and through the human skin after a single dose in the base. The absorption profiles indicate a rapid penetration to a peak flux for gabapentin occurring at approximately 4 hours after dose application, and for baclofen occurring at approximately 8 hours after dose application. The absorption profiles indicate a steady penetration to a peak flux for ketamine HCl occurring at approximately 12 hours after dose application, and for clonidine HCl occurring at approximately 32 hours after dose application. The Most Scientifically Advanced Product on the Market Today! Ketamine HCl ................................5% Gabapentin ..................................10% Clonidine HCl ............................ 0.2% Baclofen ..........................................2% SaltStable LS Advanced™ ............. qs 100% ADDITIONAL FORMULAS TESTED Baclofen .............................................2% Bupivacaine HCl ...........................1% Cyclobenzaprine HCl ..................2% Diclofenac Na .................................5% Gabapentin........................................6% Ibuprofen ............................................3% Ketamine HCl .................................10% Pentoxifylline ..................................3% SaltStable LS Advanced™ .................q.s. 100% Diclofenac Na .................................5% Ibuprofen ............................................3% Pentoxifylline ..................................3% Verapamil HCl ...............................10% SaltStable LS Advanced™ .................q.s. 100%
20Ways Fall 2013 Issue: Community - Specialty - LTC
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